Evidence of Stable Isotope 13C Causing All Cancers



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Submitted Jun 9, 2022
Published Aug 14, 2022
10.24018/ejphysics.2022.4.4.187

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Evidence for a general mechanism of genesis of all cancers is given by presenting a puzzle and using recent results of aspartame and acesulfame-K to fit the pieces of the cancer puzzle together for proof of the mechanism of oncogenesis. Aspartame and acesulfame-K have been linked to cancer. Aspartame is a modified dipeptide (methylated phenylalanine (modified) and aspartic acid), so modified amino acids were thought to be more innocuous. The author previously noted isotopically enriched and/or clumped bond-specific amino acids and oligonucleotides have different biochemical reactions for different biology. Acesulfame-K is not a peptide or oligonucleotide but it has some similar chemical structure to oligonucleoside and reversibly decomposes to affect oligonucleosides and affect cells and bacteria cells like E Coli for producing isotopically enriched amino acids indirectly. E. Coli is present in the human digestive system and is known to accelerate stable isotope enrichment of amino acids with 13C, 15N, and/or 17O. Thereby acesulfame-K and aspartame induce isotopic enrichments and excessive 13C, 15N, and/or 17O introductions into proteins and nucleic acids. Such effects of 13C isotopes as induced by the bacteria and these chemicals like aspartame and acesulfame-K may be coupled to effects of static magnetic field(s) and radio frequency electromagnetic waves for explaining the complexity of results and inconsistent results from separating these effects. Thereby the 13C isotope enriched phenylalanine and/or aspartic acid may be the basis of malfunctioning normal cells for the genesis of cancer. Further support for this theory of 13C causing cancer by ingestion of aspartame is given by also noting the mystery and confounding results of monosodium glutamate causing cancer as the glutamate is synthesized by bacterial culture and the resulting ingested glutamic acid enriched with 13C and 15N and possibly 17O causes adverse biochemistry and enzymatics (relative to glutamate from healthy plants and animals rather than the bacterial industrial glutamate in MSG) for cancer and other diseases as explaining the observation of cancer and other diseases from acute and chronic MSG ingestion over months and years. The third case of bacterial production of insulin during the last 25 years for recent correlation to insulin causing cancer relative to less cancer from older methods of insulin production is more evidence of bacterial production of amino acids and peptides causing enriched heavy isotopes and the resulting enriched amino acids and peptides causing cancer relative to ingestion of 13C enriched carbohydrates.

Keywords: Aspartame, 13C, Cancer, Nuclear Magnetic Moments, Magnetochemistry.

References

  1. 2013 private communication via emails of author.
     Google Scholar
  2. Little RB. On the Atomic Carcinogenic Mechanism and Cure for Cancer: Ferrochemistry for Cause of Warburg Effect. viXra. 2018. https://vixra.org/abs/1802.0338
     Google Scholar
  3. Krempels K, Somlyai I, Somlyai GA. Retrospective evaluation of the effects of deuterium depleted water consumption on 4 patients with brain metastases from lung cancer. Integr Cancer Ther. 2008; 7(3):172-181.
     Google Scholar
  4. Feychting M. Health effects of static magnetic fields-a review of the epidemiological evident. Progress in Biophysics and Molecular Biology. 2005; 87 (2-3): 241-246.
     Google Scholar
  5. Miller AB, Sears ME, Morgan LL, Davis DL, Hardell L, Oremus M, Soskolne CL Risks to Health and Well-Being From Radio-Frequency Radiation Emitted by Cell Phones and Other Wireless Devices. Frontiers in Public Health. 2019; 7. https://doi.org/10.3389/fpubh.2019.00223.
     Google Scholar
  6. US Food & Drug Administration. Review of Published Literature between 2008 and 2018 of Relevance to Radio Frequency Radiation and Cancer. FDA website. Published February 2020. Available from fda.gov/media/135043/download. Accessed February 12, 2020.
     Google Scholar
  7. Little R, Uziel O. Cancer Cells Possess Different Isotopic Enrichment. ChemRxiv. 2019. https://doi.org/10.26434/chemrxiv.9989711.v1
     Google Scholar
  8. Little RB. On the modulations of chemical resonance and rehybridizations by positive and negative nuclear magnetic moments. To be published in Physical Science International Journal. viXra. 2021. https://vixra.org/abs/2106.0048.
     Google Scholar
  9. Buchachenko A, Bukhvostov AA, Ermakov K, Kuznetsov DA. Nuclear spin selectivity in enzymatic catalysis: A caution for applied biophysics. Archives of Biochemistry and Biophysics. 2019; 667: 30-35.
     Google Scholar
  10. Debras C, Chazelas E, Srour B, Druesne-Pecollo N, Esseddik Y, de Edelenyi FS, Agaesse C, et al. Artificial sweeteners and cancer risk: Results from the NutriNet-Sante population-based cohort study. PLOS Medicine. 2022; https://doi.org/10.1371/journal.pmed.1003950.
     Google Scholar
  11. Sullivan LB, Luengo A, Danai LV, Bush LN, Diehl FF, Hosios AM, Lau AN, et al. Aspatate is an endogenous metabolic limitation for tumour growth. Nat Cell Biology. 2018; 20(7): 782-788.
     Google Scholar
  12. Broome JD. Evidence that the L asparginase activity of guinea pig serum is responsible for its antilymphoma effects. Nature. 1961; 191: 1114-1115.
     Google Scholar
  13. Shahriar S, Ahsan T, Khan A, Akhteruzzaman S, Shehreen S, Sajib AA. Aspartame, acesulfame K and sucralose influence on the metabolism of Escherichia coli. Metabol Open. 2020; 8:100072.
     Google Scholar
  14. Jansson M, Li YC, Jendeberg L, Anderson S, Montelione GT, Nilsson B. High-level production of uniformly 15N and 13C enriched fusion proteins in Escherichia Coli. Biomol NMR. 1996; 7(2): 131-141.
     Google Scholar
  15. Walker TE, London RE. Biosynthetic preparation of L-[13C]- and [15N] glutamate by Brevibacterium flavum. Appl Environ Microbiol. 1987; 53(1): 92-98.
     Google Scholar
  16. Miura K, Goto AS. Stable nitrogen isotopic fractionation associate with transamination of glutamic acid to aspartic acid: Implications for understanding 15N trophic enrichment in ecological food webs. Res. Org. Geochem. 2012; 28: 13-17.
     Google Scholar
  17. Ramaraju B, McFeeters H, Vogler B, McFeeters RL. Bacterial production of site specific 13C labeled phenylalanine and methodology for high level incorporation into bacterially expressed recombinant proteins. J. Biomol NMR. 2017; 67(1): 23-34.
     Google Scholar
  18. Hayes JM. Fractionation of the isotopes of C and H in biosynthetic processes. In: Mineralogical Society of America. Valley JW & Cole DR. Ed. 2001.
     Google Scholar
  19. Gauthier DR, Rivera NR, Yang H, Schultz DM, Shultz CS. Palladium-catalyzed carbon isotope exchange on aliphatic and benzoic acid chlorides. J. Am. Chem. Soc. 2018; 140(46): 15596.
     Google Scholar
  20. Hope Jahren A, Saudek C, Yeung EH, Linda Kao WH, Kraft RA, Caballero B. An isotopic method for quantifying sweeteners derived from corn and sugar cane. Am J Clin Nutr. 2006; 84: 1380-4.
     Google Scholar
  21. Yttereng J. Why Aspartame and Acesulfame-K Cause Cancer. [Internet] 2022, April 14. Available from https://sorze4.com/en/why-aspartame-and-acesulfame-k-cause-cancer/
     Google Scholar
  22. Kobetičová K, Mocová KA, Mrhálková L, Petrová R. Effects of artificial sweeteners on Lemna minor. Czech Journal of Food Sciences, 2018; 36(5): 386–391. https://doi.org/10.17221/413/2016-cjfs.
     Google Scholar
  23. Cao J, Balluff B, Arts M, Dubois LJ, van Loon LJC, Heeren RMA, et al. Mass spectrometry imaging of L-[ring-13C6]-labeled phenylalanine and tyrosine kinetics in non-small cell lung carcinoma. Cancer & Metabolism. 2021; 9: 26. DOI: 10.1186/s40170-021-00262-9.
     Google Scholar
  24. Pataskar A, Champagne J, Nagel R, Kenski J, et al. Tryptophan depletion results in tryptophan to phenylalanine substitutants. Nature. 2022; 603(7902): 721-727. DOI: 10.1038/s41586-022-04499-2.
     Google Scholar
  25. Abdallan CG, Jiang L, de Feyter H M, Fasula M, Krystal J H, Rothman DL, Mason G F, et al. Glutamate metabolism in major depression disorder. Am. J Psychiatry. 2014; 171 (2): 1320.
     Google Scholar
  26. Roman-Ramos R,Almanza-Perez JC, Garcia-Macedo R, Blancas-Flores G. Monosodium glutamate neonatal intoxication associated with obesity in adult stage is characterized by chronic inflammation and increased mRNA expression of peroxisome proliferator-activated receptors in mice. Basic Clin Pharmaol Toxicol. 2011; 108 (6): 406-13.
     Google Scholar
  27. Ortiz G G, Bitzer-Quintero OK, Beas Zarate C, Rodriguez-Reynoso S. Monosodium glutamate- induced damage in liver and kidney: a morphological and biochemical approach. Biomed Pharacother. 2006; 60(2): 86-91.
     Google Scholar
  28. Feng F, Zhou X, Wu F, Yao K, Kong X, Li T, Blachier F, Yin Y, et al. Both dietary supplementation with Monosodium L-Glutamate and fat modify circulating and tissue amino acid pools in growing pigs, but with little interactive effect. PLoS ONE. 2014;9(1):e84533. https://doi.org/10.1371/journal.pone.0084533.
     Google Scholar
  29. Kayode O T, Rotimi D E, Kayode AAA, Olaolu TD, Adeyemi OS. Monosodium glutamate (MSG) – induced male reproductive dysfunction: a Mini review. Toxics. 2020; 8(1):7.
     Google Scholar
  30. Lin Y, Yang Z, Li J, Sun Y, Zhang X, Qu Z, Luo Y, Zhang L. Effects of glutamate and aspartate on prostate cancer and breast cancer: a Mendeliam randomization study. BMC Genomics. 2022; 23 (1): 213.
     Google Scholar
  31. Skeptic.com. Safe Sweetener or Perilous Poison? [Internet] 2022; Available from https://www.skeptic.com/reading_room/aspartame-safe-sweetener-or-perilous-poison/?gclid=Cj0KCQjw4PKTBhD8ARIsAHChzRKuzTYyIb91nM7EZEo_de0XCcRmV1Qy66nwyU3w51Mbzd32xNcFwv4aAiohEALw_wcB.
     Google Scholar
  32. The University of Texas. Sugar, insulin resistance and cancer: What is the link? [Internet] 2021; Available from https://www.mdanderson.org/cancerwise/sugar--insulin-resistance-and-cancer--what-is-the-link.h00-159461634.html#:~:text=Long%2Dterm%20increased%20insulin%20raises,risk%20for%20those%20three%20cancers.
     Google Scholar
  33. Hyeon Lee J, Cho Y, Kim JH, Kim J, Nam HY, Kim SW, Son J. Branched Chain amino acids sustain pancreatic cancer growth by regulating lipid metabolism. Experimental & Molecular Medicine. 2019; 51: 1-11.
     Google Scholar
  34. Hurst R, Meader E, Gihawi A, Rallapalli G, Clark J, Kay GL, Cooper CS, et al. Microbiomes of Urine and the Prostate Are Linked to Human Prostate Cancer Risk Groups. European Urology Oncology, 2022; 5(4): 412–419. https://doi.org/10.1016/j.euo.2022.03.006.
     Google Scholar
  35. Foreman D. Gastric cancer and helicobacter pylori: a combined analysis of 12 case control studies nested within prospective cohorts. BMJ Journals 2022; 49(3): 347-353 https://gut.bmj.com/content/49/3/347.
     Google Scholar
  36. Cesarman E, Damania B, Krown SE, Martin J, Bower M, Witby D. Kaposi Sarcoma. Nat Rev Dis Primers. 2019; 5(1): 9.
     Google Scholar
  37. Durst M, Gissmann L, Ikenberg H, zur Hausen H. A papillomavirus DNA from cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions. PNAS, 1983; 80(12): 3812-3815.
     Google Scholar
  38. McNally RJQ, Eden TOB. An infectious aetiology for childhood acute leukaemia: a review of the evidence. Br J Haematol, 2004; 127(3): 243-263.
     Google Scholar
  39. Epstein MA, Achong BG, Barr YM. Virus particles in cultured lymphoblasts from Burkitt’s lymphoma. Lancet, 1964; 1(7335): 702-703.
     Google Scholar
  40. Lam KM, Syed N, Whittle H, Crawford DH. Circulating Epstein Barr virus -carrying B cells in acute malaria. Lancet, 1991; 337: 876-878.
     Google Scholar
  41. Butz DE, Casperson SL, Whigham LD. The emerging role of carbon isotope ratio determination in health research and medical dianostics. J. Anal. At. Spectrom. 2014; 29: 594-598.
     Google Scholar
  42. Zhao W, Fang J, Huang X, Zhang Y, Liu W, Wang Y, Zhang L. Carbon and hydrogen isotope fractionation in lipid biosynthesis by Sporosarcina sp. DSK25. Geochemical Perspectives Letters, 2020: 9–13. https://doi.org/10.7185/geochemlet.2016.
     Google Scholar
  43. Holden WE and Ostrom PH. Monitoring bacterial transport by stable isotope enrichment of cells applied and environmental microbiology, Sppl Environ Microbiol. 2000; 66(11): 4935-4939.
     Google Scholar
  44. Post M. Medical technology to produce food. Journal of the Science of Food and Agriculture, 2004; 94(6): 1039-1041.
     Google Scholar
  45. Sharma R, Garg P, Kumar P Bhatia SK, Kulshrestha S. Microbial fermentation and its role in improvement of fermented foods. Fermentation, 2020; 6:106.
     Google Scholar